Імунологічні аспекти профілактики передчасного розриву плодових оболонок при недоношеній вагітності

Аналіз особливостей перебігу вагітності, пологів та післяпологового періоду при передчасному розриві плодових оболонок. Розробка та обґрунтування методу профілактики передчасного розриву плодових оболонок при недоношеній вагітності у жінок групи ризику.

Рубрика Медицина
Вид автореферат
Язык украинский
Дата добавления 27.02.2014
Размер файла 48,4 K

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L.V.Begal. Immunologic aspects of premature rupture of fetal membranes prevention in case of part-term pregnancy. - Manuscript.

Thesis to obtain the scientific degree of Candidate of Medical Sciences, speciality 14.01.01 - obstetrics and gynecology. Vinnitsa State Medical University named after M.I.Pirogov, the Ministry of Public Health of Ukraine, Vinnitsa, 2001.

The thesis deals with the questions of premature rupture of fetal membranes (PRFM) prevention in case of part-term pregnancy. The above mentioned problem is one of the most important in modern obstetrics as it is closely connected with the proble of incomplete pregnancy and as a result - perinatal and maternal morbility. One of the pathogenic chains of PRFM development is the disturbance of compensator-adjustable mechanisms in the "mother - fetus" system.

The systemic immune condition in women with premature rupture of fetal membranes and the local immunosuppression function in the premature ruptured membanes have been studied. The immune system activation has been established both in the cellular and humoral links as well as in the non-specific effector system of anti-infections defense in the given group of the pregnant. The reduction of local immunosuppression in the premature ruptured membanes has been found as compared with the received data in physiologic delivery.

To prevent premature rupture of fetal membranes in case of part-term pregnancy in women of the risk group of this pathologic conditions development we have introduced the method of husband's lymphocytes immunization. This method normalizes the systemic immune condition and leads to the reduction of PRFM in case of part-term pregnancy, frequency of premature delivery in general population and improves the course of delivery, postnatal period and newborn's condition in this group of women.

Key words: premature rupture of fetal membranes, premature delivery, immune status, husband's lymphocytes immunization.

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