The effectiveness of a comprehensive treatment regimen using sodium thiosulfate with gastrointestinal diseases in calves with intoxication syndrome

The dependence of the severity on the degree of endogenous intoxication, the effectiveness of complex treatment of calves using sodium thiosulfate-based drugs for gastrointestinal diseases. The course of severity on the degree of endogenous intoxication.

Рубрика Медицина
Вид статья
Язык английский
Дата добавления 09.02.2022
Размер файла 30,4 K

Отправить свою хорошую работу в базу знаний просто. Используйте форму, расположенную ниже

Студенты, аспиранты, молодые ученые, использующие базу знаний в своей учебе и работе, будут вам очень благодарны.

Размещено на http://www.allbest.ru/

Article

The effectiveness of a comprehensive treatment regimen using sodium thiosulfate with gastrointestinal diseases in calves with intoxication syndrome

Belko A., Matsinovich M., Petrov V., Matsinovich A., Republic of Belarus, Educational Establishment "Vitebsk Order", Badge of Honor "State Academy of Veterinary Medicine"

The aim of the research was to study the dependence of the severity on the degree of endogenous intoxication and the effectiveness of complex treatment of calves using sodium thiosulfate-based drugs for gastrointestinal diseases. Studies were carried out under production conditions in cattle farms of the Vitebsk, Liozno and Gorodok districts. As preparations based on sodium thiosulfate, the veterinary drug "Averon" produced by LLC Belekotekhnika RB and the veterinary preparation Antitox manufactured by ImmCont GmbH, Germany, were used. These drugs as an antitoxic agent, were administered once a day, intravenously, slowly at a dose of 25 ml, until the clinical signs of the disease disappeared in addition to the basic treatment taken in the farms with gastrointestinal diseases.

The data obtained as a result of the analysis of the literature and the conduct of our own research showed that in the pathogenesis of gastrointestinal diseases of the calves, the link to the pathogenesis, which significantly determines the severity of their course and prognosis, is endogenous intoxication. It was found that in patients with calves, the MW content was higher at the height of the disease - 1.75-2 times with moderate severity and 1.94 and 2.47 times with severe. Laboratory criteria were established for predicting the severity of dyspepsia and abomasoenteritis in calves of 14 to 30 days of age. So, at a level higher than 0,120 conv. units in 100% of such calves, dyspepsia or gastroenteritis proceeded in a severe (toxic) form. The significant direct correlations between the concentration of MWS and LPO products (r > 0.650) revealed at the height of the disease indicate the significance of LPO as a source in the development of endotoxication in gastrointestinal diseases in calves. It has been established that the use of drugs with antitoxic action based on sodium thiosulphate in the complex therapy of calves of patients with dyspepsia and abomasoenteritis can reduce the severity and lethality of calves with dyspepsia by 5% to 10%.

Key words: calves, blood, endogenous intoxication, abomazoenteritis, dyspepsia, therapeutic efficacy, treatment.

Problem statement, analysis of basic research and publications

The basis of the pathogenesis of gastrointestinal disorders in young cattle of any origin is indigestion of the received feed, the development of dysbacteriosis and metabolic disorders [1-4, 13-16]. Endogenous intoxication is also a significant link in the pathogenesis of these diseases [5-7, 10-12], often determining their severity and outcome [8-11, 6-9]. Endogenous intoxication in gastrointestinal diseases develops by several mechanisms, but the most significant, according to many authors, is metabolic, i.e. due to metabolic disorders, namely the predominance of catabolism over anabolism, and is a complex pathogenetic complex, including disorders in almost all organs and systems of the body [3, 4, 12-16, 1, 2, 15-19]. It should also be considered as a change in the regulation of metabolism or the metabolic response of the body to any aggressive factor [17-19, 3-5].

Important in the development of endotoxicosis belongs to lipid peroxidation (LPO). Intermediate products of lipid peroxidation are toxins and make a significant contribution to the development of endotoxication [20, 21].

To eliminate the endogenous intoxication of metabolic origin, drugs are used that promote biotransformation and subsequent elimination of toxins. In veterinary practice, for this purpose, often use drugs with oxidative properties (for example, sodium hypochlorite [22] and other electroactivated solutions of sodium chloride, etc.) [23, 24].

The purpose of the research is to study the dependence of the course of severity on the degree of endogenous intoxication and the effectiveness of complex treatment of calves using sodium thiosulfate-based preparations for gastrointestinal diseases.

Materials and research methods.

Studies were carried out under production conditions in cattle farms of the Vitebsk, Liozno and Gorodok districts. In the serum of newborn calves with dyspepsia (n = 18); calves 14-30 days old (n = 23) and 2-3 months of age (n = 16), patients with gastroenteritis selected during the primary study and at the height of the disease (3-4 days), determined the concentration of medium molecular weight substances (MWS) [25] - as an integral marker of intoxication and LPO products: malonic dialdehyde (MDA) and diene conjugates (DC). To interpret the results of laboratory studies of calves, depending on the severity of the clinical manifestations of toxicosis syndrome, divided into 3 groups: mild, moderate and severe [25-27].

Further, in the conditions of Municipal unitary agricultural enterprise (MUAE) "Im. Sverdlov "Go- rodok district conducted a study of the comparative therapeutic efficacy of various integrated treatment regimens of calves with gastrointestinal diseases. It was created 6 groups of experimental animals, 20 animals each. The first group consisted of calves suffering from dyspepsia with basic treatment, the second group with the additional administration of the veterinary Antitox preparation manufactured by ImmCont GmbH, Germany, once a day, intravenously, slowly at a dose of 20 ml; in the third - with the additional administration of the veterinary drug "Averon" produced by LLC Belako- tekhnika, Belarus, once a day, intravenously, slowly at a dose of 20 ml; the fourth group consisted of calves, patients with abomasoenteritis at the age of 14-30 days with basic treatment, the fifth group - with the additional administration of the veterinary drug “Antitox” produced by “ImmCont” GmbH, Germany, once a day, intravenously, slowly at a dose of 25 ml, until the disappearance of clinical signs of the disease; in the sixth - with the additional administration of the veterinary drug "Averon" produced by LLC Belakotekhnika, Belarus, once a day, intravenously, slowly at a dose of 25 ml. Averon and antitox was administered until the disappearance of clinical signs. The basic treatment was the use of diet therapy, antimicrobial (with abomasoenteritis) and rehydration therapy. On the 4th day of treatment, blood was collected from calves to determine MWS.

Main material

intoxication thiosulfate disease

Research results

It was found that the severity of intoxication largely determines the severity of gastrointestinal diseases in calves. Thus, a significant correlation dependence (r > 0.85) was found between the concentration of MW and the duration of the disease in the calves of all experimental groups. The concentration of SMV, depending on the severity of the disease is presented in Table 1.

Table 1 - MWS, depending on the severity of gastrointestinal diseases of calves, conv. units (M ± m)

Severity

Blood taking time

Group of calves

Patients with dyspepsia

14-30 days, abomazoenteritis

2-3 months, abomazoenteritis

Easy

1

0,084±0,0061

0,077±0,0054

0,065±0,0029

2

0,095±0,00541

0,093±0,00731

0,080±0,00441

Average

1

0,107±0,00932

0,106±0,01022

0,073±0,0053

2

0,196±0,0183 1 2

0,167±0,01281' 2

0,125±0,0841, 2

Heavy

1

0,133±0,01142

0,125±0,00842

0,080±0,0062

2

0,235±0,01851, 2 3

0,184±0,01351, 2 3

0,175±0,00841' 2' 3

Note. 1 P <0.05 (compared with the first blood collection); 2 P <0.05 (compared with mild severity of the disease), 3 P <0.05 (severe form compared to the average).

Analysis of the data presented in table 1, allows you to see several trends. First, in newborn calves and calves of 14-30 days of age, the content of MWS at the onset of the disease directly correlates with the subsequent severity of its course. So, at a level higher than 0,120 conv. units in 100% of such calves, dyspepsia or gastroenteritis proceeded in a severe (toxic) form. In the calves of 2-3 months of age, this trend was no longer noted. This may be due to the etiological role of metabolic disorders in the development of these diseases [10]. Secondly, the concentration of MWS significantly increases depending on the severity of the course of gastrointestinal diseases of calves. So, in calves, patients with dyspepsia, it was higher at the height of the disease - 2 times with moderate severity and 2.47 times with severe. And with gastroenteritis in 14-30-day calves - 1.75 and 1.94 times with moderate and severe degrees of course, respectively. In 2-3- month-old calves, the trend is similar, but less pronounced. And thirdly, the intensity of the content of MWS with endotoxicosis caused by gastrointestinal disease decreases with age. As it is known, in calves with the development of acute gastrointestinal diseases, there is a tendency to enhance LPO [16], which was also detected by us. This was manifested in the increase in the content of both primary and secondary LPO products. Moreover, the tendency to an increase in the concentration of LPO products was similar to that of the MWS content (Table 2).

Table 2 - LPO products, depending on the severity of gastrointestinal diseases of calves, cond. units (M±m)

Severity

Blood taking time

Group of calves

Patients with dyspepsia

14-30 days, abomazoenteritis

2-3 months, abomazoenteritis

MDA, pmol/l

Easy

1

2,24±0,132

1,67±0,133

1,35±0,094

2

2,65±0,1061

2,05±0,1841

1,66±0,1021

Average

1

2,17±0,284

1,75±0,169

1,53±0,085

2

2,99±0,0871' 2

2,18±0,0931

2,02±0,1021

Heavy

1

2,83±0,1232

1,83±0,125

1,58±0,133

2

3,65±0,2061' 2' 3

2,67±0,1361' 2' 3

2,23±0,1421' 2

DC, D232/ mg lipids

Easy

1

0,284±0,168

0,234±0,076

0,225±0,159

2

0,345±0,1971

0,285±0,2141

0,249±0,193

Average

1

0,305±0,235

0,256±0,093

0,233±0,160

2

0,386±0,1641, 2

0,307±0,1931' 2

0,275±0,2081

Heavy

1

0,313±0,211

0,275±0,111

0,240±0,193

2

0,435±0,3651, 2 3

0,349±0,0841' 2' 3

0,315±0,1271' 2' 3

Note. 1 P <0.05 (compared with the first blood collection); 2P <0.05 (compared with mild severity of the disease); 3 P <0.05 (severe form compared to the average)

As can be seen from table 2 in calves with gastrointestinal diseases, the intensity of the LPO increases, which is manifested by the accumulation of both intermediate (DC) and final reaction products (MDA). In calves, both in dyspepsia and abomazoenteritis, their concentration depends on the severity of the disease. Correlation analysis showed the presence of a significant direct relationship between the concentration of MWS and MDA (at the primary study in calves with dyspeptic patients r = 0.673, and at the height of the disease - r = 0.756), between MWS and DC (at primary research in calves with dyspeptic patients r = 0.712, and in the midst of the disease - r = 0.791). This indicates the importance of the LPO in the development of endotoxin in gastrointestinal diseases of calves.

In calves, which, in addition to the basic treatment, antitoxic drugs were used, by the 4th day of treatment, the MWS level was significantly lower and was: in calves, patients with dyspepsia in the baseline treatment group - 0.184 ± 0.0149 conv. units, in the treatment with the veterinary drug "Aveyron" - 0,147 ± 0,0131 conv. units, in the treatment with the drug veterinary "Antitoks" - 0,140 ± 0,0118 conv. units, and in calves, patients with abomazoenteritis in the group of basic treatment - 0.171 ± 0.0125 conv. units, with the treatment with the veterinary drug "Aveyron" - 0.122 ± 0.0097 conv. units, in the treatment with the drug veterinary "Antitoks" - 0,117 ± 0,0112 conv. units It was found that the use of sodium thiosulfate in the therapeutic regimen can significantly reduce the severity and duration of the disease of the calves with gastrointestinal diseases. So, in the group of basic treatment of calves with dyspepsia, the duration of treatment was 5.6 ± 0.54 days, mortality - 15%, the number of cases with severe course (toxic dyspepsia) - 25%. In the groups using Averon and antitox, these indicators were respectively: the disease duration was 4.0 ± 0.36 and 3.7 ± 0.35 days, the mortality rate was 5 and 10%, the number of severe cases (toxic dyspepsia) was ten percent. In the experimental groups, where anti-toxic drugs were used, the positive dynamics of recovery was observed already on the second day in most calves, which was manifested by a decrease in the intensity of diarrhea, on the third to fourth days in all animals of the experimental group, the main clinical sign disappeared - diarrhea. In calves, there was a recovery in appetite and water intake returned to normal. And in the group of basic treatment of calves with abomazoenteritis, the duration of treatment was 4.8 ± 0.43 days, mortality - 10%, the number of cases with a severe course - 20%. In the groups using Averon and antitox, these indicators were respectively: the duration of the disease was 4.1 ± 0.29 and 3.9 ± 0.30 days, the mortality rate was 5%, the number of cases with severe disease was 10%.

Conclusion

The data obtained as a result of the analysis of the literature and the conduct of our own research show that in the pathogenesis of gastrointestinal diseases of calves, the link of pathogenesis that significantly determines the severity of their course and prognosis is endogenous intoxication. The use of dyspepsia and abomasoenteritis in the complex treatment of calves of patients with dyspepsia, drugs with sodium thiosulfate antitoxic action, reduces the severity and mortality in calf dyspepsia by 5-10%, and in abomasoenteritis by 5%. In the dynamics of therapy, along with a positive effect on clinical symptoms, a significant decrease in the concentration of SMV was observed (at the level of significant differences - p <0.05) as a marker of endotoxication.

Список літератури

1. Gomez-Nieto D. Investigations in calf diarrhea: bovine coronavirus. Intestinal microbiota, and antimicrobial usage. Guelph, Ontario, Canada, 2017. 182p.

2. Ильинский Е.В., Габриелян К.Г. Острые расстройства пищеварения у новорожденных телят. Ветеринария сельскохозяйственных животных. 2006. № 1. С. 67-70.

3. Скорых Е.А. Обмен веществ у новорожденных телят в норме и при диспепсии: дис. ... канд. вет. наук: 06.00.01/Алтайский гос. ун-т. Барнаул, 2015. 126 с.

4. Лютинский С.И. Патологическая физиология животных: учебник для вузов. 3 изд., испр и доп. Москва: ГЭОТАР-Медиа, 2011.560 с.

5. Осипова Н.И. Эндогенная интоксикация у телят при диарее. Ветеринария. Реферативный журнал. 2006. № 2. С. 389.

6. Бурова О.А., Исаев В.В., Блохин А.А. Эндогенная интоксикация при желудочно-кишечных болезнях телят. Вопросы нормативно-правового регулирования в ветеринарии. 2014. № 2. С. 105-108.

7. Эндотоксикоз при абомазоэнтеритах у телят/ А.А. Белко и др. Науковий вісник ветеринарної медицини. 2016. № 1 (127). С. 24-31.

8. Gaieski D.F., Edwards J.M., Kallan M.J., Carr B.G. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit.Care Med. 2013. Vol. 41. N. 5. P. 1167-1174.

9. Павелкина В. Ф., Щипакина С. В., Пак С. Г., Еровиченков А. А. Динамика показателей эндогенной интоксикации у больных повторными ангинами. Врач. 2008. № 11. С. 64-66.

10. Рахматулин Э.К., Зорина О.Н. Биохимическое обоснование действия полигимина на телят. Вестник РАСХН. 2008. № 4. С. 67-68.

11. Пак С. Г., Белая О. Ф., Малов В. А. Опыт и перспективы изучения синдрома интоксикации в инфекционной патологии. Журн. инфектол. 2009. Т. I. № 1. С. 9-17.

12. Перекисное окисление липидов и эндогенная интоксикация у животных: монография / С.С. Абрамов и др. Витебск: УО ВГАВМ, 2007. 208с.

13. Сачков Н.В., Федоровский Н.М. Этиология и патогенез полиорганной дисфункции. Новости анестезиол. и реаниматол. 2007. № 2. C. 20-33.

14. Эндоинтоксикация при абомазоэнтеритах у телят/ А.А. Белко и др. Ветеринарный журнал Беларуси. 2016. № 3 (5). С. 15-19.

15. Пасько М.Н. Нефрогенный и метаболический ацидоз при диспепсии у новорожденных телят: дис. ... канд. вет. наук: 06.00.01/ Алтайский гос. ун-т. Барнаул, 2012. 135 с.

16. Podhorsky A. Metabolic disorders in dairy calves in postpartum period. ActaVeterinaria Brno. 2007. Vol. 76. №. 8. Р. 45-53.

17. Белко А.А., Богомольцева М.В. Среднемолекулярные вещества - показатель степени эндогенной интоксикации организма у телят. Актуальные проблемы интенсивного развития животноводства. Горки, БГСХА, 2011. Вып. 14. Ч. 2. С.189-196.

18. The effect of taurine on polymorphonuclear leukocyte functions in endotoxemia/ Н. Erdamar et al. Amino Acids. 2007. № 4. Р. 581-585.

19. Endotoxins: structure, function and recognition/ X. Wang, P. Quinn (eds.). Springer, 2010. 417 p.

20. Клычникова Е.В. Оценка прогностической значимости биохимических маркеров окислительного стресса, эндогенной интоксикации и сосудистой регуляции в развитии неблагоприятных исходов у больных сепсисом. Журнал им. Н.В. Склифософского: Неотложная медицинская помощь. 2016. № 2. С. 25-30.

21. Сидельникова В.И., Черницкий А.Е., Рецкий М.И. Эндогенная интоксикация и воспаление: последовательность реакций и информативность маркеров. Сельскохозяйственная биология. 2015. Том 50. № 2. С. 152-161.

22. Абрамов С.С., Белко А.А., Мацинович А.А., Столбовой Д.А. Опыт применения раствора натрия гипохлорита в ветеринарной практике. Вісник Білоцерковского державного аграрного університету. 2010. Вип. 5 (78). С. 5-9.

23. Богомольцева М. В. Терапевтическая эффективность католита при диспепсии у телят. Актуальные проблемы обмена веществ у сельскохозяйственных животных в современных условиях: материалы международной научнопрактической конференции, посвященной 40-летию ГНУ ВНИВИПФиТ. (г. Воронеж, 30 сентября - 2 октября 2010 г.). Воронеж: ВНИВИПАТФ и Т., 2010. С. 57-60.

24. Белко А.А. Методические рекомендации по использованию электроактивированного раствора анолита для лечения и профилактики желудочно-кишечных заболеваний телят: утв. начальником Главного управления ветеринарии 14 марта 2011 г. Витебск, 2011. 20 с.

25. Мацинович А.А. Определение среднемолекулярных веществ (СМ-веществ) в сыворотке крови как индикатор интоксикационных процессов при диспепсии телят. Актуальные проблемы патологии сельскохозяйственных животных: материалы Междунар. науч.-практич. конференции, посвященной 70-летию со дня образования БелНИ- ИЭВ им. С.Н. Вышелесского (5-6 октября 2000 г.). Минск: БелНИИЭВ им. С.Н. Вышелесского. 2000. С. 518-520.

26. Методические положения по изучению процессов свободнорадикального окисления и системы антиоксидантной защиты организма/ М.И. Рецкий и др. Воронеж: ГНУ ВНИВИПФиТ, 2010. 70 с.

27. Биохимия мембран: метод. пособие к лабораторным занятиям для студентов биологического факультета спец. 1 - 31.01.01 Биология/ Авт.-сост. Н.М Орел. Минск: БГУ, 2010. 28 с.

28. Gomez-Nieto, D. (2017). Investigations in calf diarrhea: bovine coronavirus. Intestinal microbiota, and antimicrobial usage. Guelph, Ontario, Canada, 182 p.

29. Il'inskij, E.V., Gabrielyan, K.G. (2006). Ostrye rasstrojstva pishchevareniya u novorozhdennyh telyat [Acute digestive disorders in newborn calves]. Veterinariya sel'skohozyajstvennyh zhivotnyh [Veterinary farm animals]. no. 1, pp. 67-70.

30. Skoryh, Е.А. (2015). Obmen veshchestv u novorozhdennyh telyat v norme i pri dispepsii. Dis. kand. vet. nauk: 06.00.01 [A metabolism at newborn calfs in norm and at dyspepsia: the dissertation of the candidate of veterinary sciences: 06.00.01.]. Altajskij gos. universitet [Altai State University]. Barnaul, 126 p.

31. Lyutinskij, S.I. (2011). Patologicheskaya fiziologiya zhivotnyh: uchebnik dlya vuzov, 3 izd., ispr i dop. [Pathological physiology of animals: a textbook for universities. 3rd ed., Corr. And add.]. Moscow: GEOTAR-Media, 560 p.

32. Osipova, N.I. (2006). Endogennaya intoksikaciya u telyat pri diaree [Endogenous intoxication in calves with diarrhea]. Veterinariya. Referativnyj zhurnal [Veterinary Medicine. Review Journal]. no. 2, 389 p.

33. Burova, O.A., Isaev, V.V., Blohin, A.A. (2014). Endogennaya intoksikaciya pri zheludochno-kishechnyh boleznyah telyat [Endogenous intoxication in gastrointestinal diseases of calves]. Voprosy normativno-pravovogo regulirovaniya v vet- erinarii [Regulatory issues in veterinary medicine]. no. 2, pp. 105-108.

34. Belko, A.A., Macinovich, A.A., Baran, V.P., Bogomol'ceva, M.V. (2016). Endotoksikoz pri abomazoenteritah u telyat [Endotoxicosis with avomasodenitis in calves]. Naukovij vіsnik veterinarnoї medicine [Scientific journal of veterinary medicine]. no. 1 (127), pp. 24-31.

35. Gaieski, D.F., Edwards, J.M., Kallan, M.J., Carr, B.G. (2013). Benchmarking the incidence and mortality of severe sepsis in the United States. Crit.Care Med. Vol. 41, no. 5, pp. 1167-1174.

36. Pavelkina, V.F., Shchipakina, S.V., Pak, S.G., Еrovichenkov, A.A. (2008). Dinamika pokazatelej endogennoj intoksikacii u bol'nyh povtornymi anginami [Dynamics of indices of endogenous intoxication in patients with repeated angina]. Vrach [Doctor]. no. 11, pp. 64-66.

37. Rahmatulin, E.K., Zorina, O.N. (2008). Biohimicheskoe obosnovanie dejstviya poligimina na telyat [Biochemical rationale for the action of polyhymine on calves]. Vestnik RASKHN [Bulletin of the Russian Academy of Agricultural Sciences]. no. 4, pp. 67-68.

38. Pak, S.G., Belaya, O.F., Malov, V.A. (2009). Opyt i perspektivy izucheniya sindroma intoksikacii v infekcionnoj patologii [Experience and prospects of studying intoxication syndrome in infectious diseases]. Zhurn. Infektol [Journal of Infectology]. Vol. I, no.1, pp. 9-17.

39. Abramov, S.S., Belko, A.A., Macinovich, A.A., Kurdeko, A.P. (2007). Perekisnoe okislenie lipidov i endogennaya intoksikaciya u zhivotnyh: monografiya [Lipid peroxidation and endogenous intoxication in animals: monograph]. Vitebsk, UO VGAVM, 208 p.

40. Sachkov, N.V., Fedorovskij, N.M. (2007). Etiologiya i patogenez poliorgannoj disfunkcii [Etiology and pathogenesis of multiorgan dysfunction]. Novosti anesteziol. i reanimatol [Anesthesiology and Resuscitation News]. no. 2, pp. 20-33.

41. Belko, A.A., Macinovich, A.A., Baran, V.P., Bogomol'ceva, M.V. (2016). Endointoksikaciya pri abomazoenter- itah u telyat [Endointoxication with calves abomazoenteritis]. Veterinarnyj zhurnal Belarusi [Veterinary Journal of Belarus]. no. 3 (5), pp. 15-19.

42. Pas'ko, M.N. (2012). Nefrogennyj i metabolicheskij acidoz pri dispepsii u novorozhdennyh telyat: dis. kand. vet. nauk: 06.00.01 [Nephrogenic and metabolic acidosis in dyspepsia in newborn calves: the dissertation of the candidate of veterinary sciences: 06.00.01]. Аltajskij gos. universitet [Altai State University]. Barnaul, 135 p.

43. Podhorsky, A. (2007). Metabolic disorders in dairy calves in postpartum period. Acta Veterinaria Brno. Vol. 76, no. 8, pp. 45-53.

44. Belko, A.A., Bogomol'ceva, M.V. (2011). Srednemolekulyarnye veshchestva - pokazatel' stepeni endogennoj intoksikacii organizma u telyat [Medium-molecular substances - an indicator of the degree of endogenous intoxication of the body in calves]. Aktual'nye problemy intensivnogo razvitiya zhivotnovodstva [Actual problems of intensive development of livestock]. Gorki, BSAA. Issue 14, Part 2, pp. 189-196.

45. Erdamar, H., Turkozkan, H., Ekremoglu, N., Kurt, M., Yaman, H. (2007). The effect of taurine on polymorphonuclear leukocyte functions in endotoxemia. Amino Acids. no. 4, pp. 581-585.

46. Wang, X., Quinn, P., (eds.). (2010). Endotoxins: structure, function and recognition. Springer, 417 p.

47. Klychnikova, E.V. (2016). Ocenka prognosticheskoj znachimosti biohimicheskih markerov okislitel'nogo stressa, endogennoj intoksikacii i sosudistoj regulyacii v razvitii neblagopriyatnyh iskhodov u bol'nyh sepsisom [Evaluation of the prognostic value of biochemical markers of oxidative stress, endogenous intoxication and vascular regulation in the development of adverse outcomes in patients with sepsis]. Zhurnal im. N.V. Sklifosofskogo: Neotlozhnaya medicinskaya pomoshch [Journal them. N.V. Sklifosofskogo: Emergency medical care]. no. 2, pp. 25-30.

48. Sidel'nikova, V.I., Chernickij A.E., Reckij, M.I. (2015). Endogennaya intoksikaciya i vospalenie: posledovatel'nost' reakcij i informativnost' markerov [Endogenous intoxication and inflammation: the sequence of reactions and the information content of markers]. Sel'skohozyajstvennaya biologiya [Agricultural Biology]. Vol. 50, no. 2, pp. 152-161.

49. Abramov, S.S., Belko, A.A., Macinovich, A.A., Stolbooj, D.A. (2010). Opyt primeneniya rastvora natriya gipohlorita v veterinarnoj praktike [Experience of using sodium hypochlorite solution in veterinary practice]. Visnik Bilocerkovskogo Derzhavnogo agrarnogo universitetu [Bulletin of the Bilotserkiv State Agrarian University]. Vol. 5 (78), pp. 5-9.

50. Bogomol'ceva, M. V. (2010). Terapevticheskaja jeffektivnost' katolita pri dispepsii u teljat [Therapeutic efficacy of catholyte with dyspepsia in calves]. Materialy mezhdunarodnoj nauch.-praktich. konferencii, posvyashchennoj 40-letiyu GNU VNIVIPFiT “Aktual'nye problemy obmena veshchestv u sel'skohozyajstvennyh zhivotnyh v sovremennyh usloviyah” [Materials of the international scientific-practical conference dedicated to the 40th anniversary of the SSI A-RSRVIPPT "Actual problems of metabolism in farm animals in modern conditions]. 30 September - 2 October 2010, Voronezh, pp. 57-60.

51. Belko, A.A. (2011). Metodicheskie rekomendacii po ispol'zovaniyu elektroaktivirovannogo rastovora anolita dlya lecheniya i profilaktiki zheludochnokishechnyh zabolevanij telyat: utv. nachal'nikom Glavnogo upravlenija veter- inarii 14 marta 2011 g. [Guidelines for the use of electroactivated anolyte solution for the treatment and prevention of gastrointestinal diseases in calves: approved. Head of the Main Veterinary Administration on March 14, 2011]. Vitebsk, 20 p.

52. Macinovich, A.A. (2000). Opredelenie srednemolekuljarnyh veshhestv (SM-veshhestv) v syvorotke krovi kak indi- kator intoksikacionnyh processov pri dispepsii teljat [Determination of weight of substances (SM-substances) in the serum as an indicator of intoxication processes in calf dyspepsia]. Aktual'nye problemy patologii sel'skohozjajstvennyh zhivotnyh: materialy Mezhdunar. nauch.-praktich. konferencii, posvjashhennoj 70-letiju so dnja obrazovanija BelNIIJeV im. S.N. Vyshelesskogo (5-6 oktjabrja 2000 g.) [Actual problems of pathology of farm animals: materials of the Intern. scientific practical conference dedicated to the 70th anniversary of the BelNIIEV S.N. Vysheleskogo (October 5-6, 2000)]. Minsk: BelNIIEV them. S.N. Vysheleskogo. pp. 518-520.

53. Reckij, M.I., SHabunin, S.V., Bliznecova G.N., Rogacheva T.N. (2010) Metodicheskie polozheniya po izucheniyu processov svobodnoradikal'nogo okisleniya i sistemy antioksidantnoj zashchity organizma [Methodical provisions on the study of free radical oxidation processes and the antioxidant defense system of the body]. Voronezh, GNU VNIVIPFiT. 70 p.

54. Orel, N.M. (eds.). (2010). Biohimiya membran: metod. posobie k laboratornym zanyatiyam dlya studentov biolog- icheskogo fakul'teta spec. 1 - 31.01.01 Biologiya [Membrane biochemistry: method. manual for laboratory classes for students of the Faculty of Biology special. 1 - 31.01.01 Biology]. Minsk, BSU, 28 p.

Ефективність комплексної схеми лікування з використанням препаратів натрію тіосульфату при шлунково- кишкових хворобах телят з синдромом інтоксикації

Бєлко А.А., Мацинович М.С., Петров В.В., Мацинович А.О.

Метою досліджень було вивчення залежності складності перебігу шлунково-кишкових хвороб телят від ступеня ендогенної інтоксикації та ефективності комплексного лікування із використанням препаратів на основі натрію тіосульфату.Дослідження проводили у виробничих умовах у скотарських господарствах Вітебського, Ліоз- ненского і Городоцького районів. Використовували препарати на основі натрію тіосульфату, а саме: препарат ветеринарний «Аверон» виробництва ТОВ «Белекотехніка» РБ і препарат ветеринарний «Антітокс» виробництва «ImmCont» GmbH, Німеччина. Ці препарати, як антитоксичний засіб, вводили один раз на добу, внутрішньовенно, повільно в дозі 25 мл, до зникнення клінічних ознак хвороби додатково до базового лікування, прийнятого в господарствах за шлунково-кишкових хвороб.

Отримані в результаті аналізу літератури та проведення власних досліджень дані показали, що в патогенезі шлунково-кишкових хвороб телят ланкою, що зумовлює складність перебігу і прогноз, є ендогенна інтоксикація. Встановлено, що у хворих телят вміст СМВ був вище в розпал хвороби - в 1,75-2 рази за середнього ступеня тяжкості і у 1,94 і 2,47 рази - за тяжкого. Визначені лабораторні критерії прогнозу тяжкості перебігу диспепсії і абомазоентериту у телят 14-30-добового віку.Так за рівня вище, ніж 0,120 ум.од., у 100 % таких телят диспепсія або гастроентерит перебігали у важкій (токсичній) формі. Виявлені в розпал хвороби значущі прямі кореляційні залежності між концентрацією СМВ та продуктами ПОЛ (r>0,650) свідчать про значущість ПОЛ як джерела розвитку ендоінто- ксикації за шлунково-кишкових хвороб у телят. Встановлено, що застосування в комплексній терапії телят, хворих на диспепсію і абомазоентерит, препаратів на основі натрію тіосульфату, дозволяє знизити тяжкість перебігу і летальність за диспепсії телят на 5-10 %, а за абомазоентериту - на 5 %.

Ключові слова: телята, кров, ендогенна інтоксикація, абомазоентерит, диспепсія, терапевтична ефективність, лікування.

Эффективность комплексной схемы лечения с ипользованием препаратов натрия тиосульфата при желудочно-кишечных болезнях телят с синдромом интоксикации

Белко А.А., Мацинович М.С., Петров В.В., Мацинович А.А.

Целью исследований было изучение зависимости тяжести течения желудочно-кишечных болезней телят от степени эндогенной интоксикации и эффективности комплексного лечения, с использованием препаратов на основе натрия тиосульфата.Исследования проводили в производственных условиях в скотоводческих хозяйствах Витебского, Лиозненского и Городокского районов. В качестве препаратов на основе натрия тиосульфата использовали препарат ветеринарный «Аверон» производства ООО «Белэкотехника» РБ и препарат ветеринарный «Антитокс» производства «ImmCont» GmbH, Германия. Данные препараты, в качестве антитоксического средста, вводили один раз в сутки, внутривенно, медленно в дозе 25 мл, до исчезновения клинических признаков болезни дополнительно к базовому лечению принятому в хозяйствах, при желудочно-кишечных болезнях.

Полученные в результате анализа литературы и проведения собственных исследований данные показали, что в патогенезе желудочно-кишечных болезней телят звеном патогенеза, значительно определяющим тяжесть течения и прогноз, является эндогенная интоксикация. Установлено, что у больных телят содержание СМВ было выше в разгар болезни - в 1,75- 2 раза при средней степени тяжести и в 1,94 и 2,47 раза - при тяжелой. Определены лабораторные критерии прогноза тяжести течения диспепсии и абомазоэнтерита у телят 14-30-суточного возраста.При уровне выше чем 0,120 усл.ед. у 100 % телят диспепсия или гастроэнтерит протекали в тяжелой (токсической) форме. Выявленные в разгар болезни значимые прямые корреляционные зависимости между концентрацией СМВ и продуктами ПОЛ (г>0,650) свидетельствуют о значимости ПОЛ как источника в развитии эндоинтоксикации при желудочнокишечных болезнях у телят. Установлено, что применение в комплексной терапии телят, больных диспепсией и абомазоэнтеритом, препаратов, обладающих антитоксическим действием на основе натрия тиосульфата, позволяет снизить тяжесть течения и летальность при диспепсии телят на 5-10 %, а при абомазоэнтерите - на 5%.

Ключевые слова: телята, кровь, эндогенная интоксикация, абомазоэнтерит, диспепсия, терапевтическая эффективность, лечение.

Размещено на Allbest.ru

...

Подобные документы

  • Concept and characteristics of focal pneumonia, her clinical picture and background. The approaches to the diagnosis and treatment of this disease, used drugs and techniques. Recent advances in the study of focal pneumonia. The forecast for recovery.

    презентация [1,5 M], добавлен 10.11.2015

  • The physiological, hygienic and epidemiological value of water. Diseases associated with water factor. Measures to prevent transmission of infectious diseases through the water. Influence of biological factors on survival of microorganisms in water.

    презентация [762,9 K], добавлен 17.05.2016

  • Gastroesophageal reflux disease. Factors contributing to its the development. Esophageal symptoms of GERD. Aim of treatment. Change the life style. A basic medical treatment for GERD includes the use of prokinetic drugs with antisecretory agents.

    презентация [390,7 K], добавлен 27.03.2016

  • Etiology and pathogenesis, types, treatment of pulpits. Inflammation of dental pulp. An infection (microorganisms) which penetrats in the cavity of pulp chamber. Test of healthy pulp. Tapping of tooth directly. Root canal treatment. Tooth extraction.

    презентация [851,9 K], добавлен 31.05.2016

  • The pathological process Acute Respiratory Distress Syndrome (ARDS). Specific challenges in mechanical ventilation of patients with ARDS. Causes of ARDS, and differential diagnosis. Treatment strategies and evidence behind them. Most common causes ARDS.

    презентация [2,6 M], добавлен 21.05.2015

  • The main clinical manifestation of intestinal lymphangiectasia is a syndrome of malabsorption: diarrhea, vomiting, abdominal pain. In some cases, steatorrhea of varying severity occurs. Cystic cavity, deforming the villus. Hematoxylin and eosin stein.

    статья [20,9 K], добавлен 29.09.2015

  • Agranulocytosis - pathologic condition, which is characterized by a greatly decreased number of circulating neutrophils. Epidemiology and pathophysiology of this disease. Hereditary disease due to genetic mutations. Signs and symptoms, treatment.

    презентация [1,8 M], добавлен 25.02.2014

  • Pneumonia is an inflammatory condition of the lung—affecting primarily the microscopic air sacs known as alveoli. The bacterium Streptococcus pneumoniae is a common cause of pneumonia. Symptoms, diagnostics, treatment and prevention of this disease.

    презентация [279,8 K], добавлен 12.11.2013

  • Principles and types of screening. Medical equipment used in screening. identify The possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms. Facilities for diagnosis and treatment. Common screening programmes.

    презентация [921,2 K], добавлен 21.02.2016

  • The complement system - part of the immune system as a set of complex proteins. History of the concept. Its biological functions, regulation, role in diseases. Stages of activation: the alternative and lectin pathway. Mannose-binding Lectin deficiency.

    презентация [932,7 K], добавлен 17.03.2017

  • The major pathogens and symptoms of cholera - an acute intestinal anthroponotic infection caused by bacteria of the species Vibrio cholerae. Methods of diagnosis and clinical features of disease. Traditional methods of treatment and prevention of disease.

    презентация [1,0 M], добавлен 22.09.2014

  • Infectious hepatitis - a widespread acute contagious disease. Botkin’s Disease is a viral disease that destroys the liver and bile ducts. Anatomy of the liver. The value of the liver to the body. Causes and signs of the disease. Treatment and prevention.

    презентация [4,0 M], добавлен 24.04.2014

  • The characteristic features of the two forms of eating disorders: anorexia nervosa and bulimia. Description body dysmorphic disorder syndrome as a teenager painful experiences of his "physical disability." Methods of treatment and prevention of disease.

    курсовая работа [17,9 K], добавлен 31.03.2013

  • Learning about peptic ulcers, a hole in the gut lining of the stomach, duodenum or esophagus. Symptoms of a peptic ulcer. Modified classification of gastroduodenal ulcers. Macroscopic and microscopic appearance. Differential diagnosis and treatment.

    презентация [1,2 M], добавлен 22.04.2014

  • Acromegaly as an rare syndrome that result when the anterior pituitary gland produces excess growth hormone. Signs and symptoms, etiology and pathogenesis. The complications of acromegaly. Treatment: Hormone therapy, surgery on the pituitary gland.

    презентация [827,4 K], добавлен 28.12.2015

  • Testosterone is the primary male sex hormone that is present in both men and women. How to get a test for testosterone correctly. Testosterone in men: the norm and deviation. What diseases involve reduction of testosterone. Too much testosterone.

    презентация [498,5 K], добавлен 26.05.2013

  • Churg-Strauss syndrome, microscopic polyangiitis as one of the basic types of the small vessel vasculitis. Specific features of differential diagnosis of pulmonary-renal syndrome. Characteristics of the anti-neutrophil cytoplasmic autoantibodies.

    презентация [8,2 M], добавлен 18.10.2017

  • Introduction to the functionality of the most important internal organs. The main causes of supraventricular and ventricular tachycardia. Features of the structure and basic functions of the human heart. The study of the three phases of the heart.

    презентация [3,8 M], добавлен 12.05.2013

  • Respiratory system brief. Structure of the Lungs. Structure of the Lungs. Examples of ailments of the lung: asthma, emphysema, pneumonia, tuberculosis. The characteristics and causes of diseases that cause them.. Visual of healthy vs. non healthy lungs.

    презентация [162,8 K], добавлен 27.11.2013

  • Epilepsy is a group of neurological diseases characterized by epileptic seizures. Epileptic seizures are episodes that can vary from brief and nearly undetectable to long periods of vigorous shaking. Differential diagnosis and prevention of epilepsy.

    презентация [39,6 K], добавлен 28.12.2015

Работы в архивах красиво оформлены согласно требованиям ВУЗов и содержат рисунки, диаграммы, формулы и т.д.
PPT, PPTX и PDF-файлы представлены только в архивах.
Рекомендуем скачать работу.