Главная Коллекция "Revolution" Медицина Комплексне лікування хронічного панкреатиту з використанням електромагнітного випромінювання надвисокої частоти і тіотріазоліну

Комплексне лікування хронічного панкреатиту з використанням електромагнітного випромінювання надвисокої частоти і тіотріазоліну

Дослідження зміни показників клітинного і гуморального імунітету та окисно-відновної системи у хворих на хронічний панкреатит. Оцінка клінічної ефективності застосування в лікуванні електромагнітного випромінювання надвисокої частоти та тіотріазоліну.

Рубрика Медицина
Вид автореферат
Язык украинский
Дата добавления 22.02.2014
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CP exacerbation was accompanied by POL system activation, confirmed by the primary (CD, p<0.05) and secondary (MDA, p<0.05) POL products accumulation, increased tissue's ability to PF, (p<0.05). OG concentration increased while RG, (p<0.05), vit.A and E, SOD decreased, (p<0.05).

We did not reveal precise dependance between the level of immunity indexes change, POL-AOP and sex. The older the patients were the more decreased cellular immunity indexes and BTLR with PhHA they had, vit.A and E deficiency developed, although no trustworthy difference between the indexes of the compared age groups was revealed.

In case of secondary CP hyperimmunoglobulinemia level was higher than the one in primary CP, (p<0.05), though CIC concentration in blood of patients with primary CP was higher than in patients with secondary CP, (p<0.05). In addition to this, in primary CP vit.A and E as well as SOD concentration in blood was in fact lower than in secondary CP which testifies to primary weaker condition of enzymatic and nonenzymatic AOP links.

Immunity indexes in most cases of CRP (69.9%) and CP (78.4%) were changed in the same direction and corresponded to those, described earlier and probably testified to the development of immune dysbalance in autoimmune direction. At the same time the decrease of both cellular and humoral immunity indexes in 16.2% patients with CP, accompanied by clinical signs of pancreas functional insufficiency testified to the development of secondary immunodeficiency.

POL-AOP indexes' changes in 93.9% CRP and 75.7% CP cases had the same direction and corresponded to those, described earlier. In comparison with CRP patients CD, MDA, PF, RG, OG contents in blood of patients with CP was not different from normal, while SOD, vit.A and E contents was much lower, (p<0.05).

The revealed changes in immunity and POL-AOP indexes were used to approach rationally the administration of remedies for their pharmacologic and physiotherapeutic correction. With this aim the patients were divided into 4 groups: I group (n=28) underwent only basic therapy, II group (n=30) - in addition had the course of EMR SHF with “Electronyca SHF-102” apparatus on E36, Gi 4, VB34 and VB 24s, F13s in turn, frequency 61.5+2.1 GHz, power density no more then 10mW/cm2 ; III group (n=37) - in addition took thiotryazolyn for 3-5 days parenteraly (150 mg per day), then enteraly (300mg per day); IV group (n=25) on the background of basic therapy were administered thiotryazolyn and EMR SHF. The course of treatment was 10-14 days.

The analysis of changes in immunity and POL-AOP indexes under the influence of various therapeutic shemes revealed that the first complex, while providing positive clinic-laboratory dynamics of disease in fact did not influence the immunity and oxidation-reduction system. The most significant nonspecific immunomodulation effect in EMR SHF and antioxidant effect in thiotryazolyn provided the development of the more complete clinico-laboratory remission of disease. Efficiency of the II and III complexes was higher in CRP cases with short case history (<5 years), middle form of disease. The highest efficiency both in the main clinical symptoms and in primarily changed immunuty, and POL-AOP indexes was observed when treating CP patients with the use of IV complex, as the preliminary course of antioxidant treatment with thiotryazolyn contributed to more effective EMR SHF immune changes correction and to the development of the most complete clinic-laboratory remission in patients with CRP, middle and severe form.

So, in comparison with traditional methods of CP therapy the one, suggested by us, contributed to the development of the main clinic-laboratory manifestations of disease by means of decreased immune and metabolic disorders and as a result decreased duration of in-patient treatment, from 24.6+1.13 to 18.42+0.71 bed-days.

Key words: chronic pancreatitis, immunity, peroxide lipid oxidation, antioxidant protection, superhigh frequency electromagnetic emanation, thiotryazolyn.

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