Оптимізація діагностики та лікування хворих на гострий інфаркт міокарда та ожиріння з урахуванням рівнів копептину та проадреномедуліну

Роль та значення копептину, MRproADMі тропоніну при гострому інфаркті міокарда залежно від його перебігу з урахуванням наявності у хворих супутнього ожиріння. Опис стратифікації ризику ускладненого перебігу гострого інфаркту міокарда при ожирінні.

Рубрика Медицина
Вид диссертация
Язык украинский
Дата добавления 26.06.2018
Размер файла 693,9 K

Отправить свою хорошую работу в базу знаний просто. Используйте форму, расположенную ниже

Студенты, аспиранты, молодые ученые, использующие базу знаний в своей учебе и работе, будут вам очень благодарны.

99. Rivier C. Interaction of corticotrophin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo / C. Rivier, W. Vale // Endocrinology. - 1983. - Vol. 113, N 3. - Р. 939-942.

100. Augmentation of the response to CRF in man: relative contributions of endogenous angiotensin and vasopressin / S. R. Milsom, J. V. Conaglen, R. A. Donald // Clin Endocrinol (Oxf). - 1985. - Vol. 22, N 5. - Р. 623-629.

101. Incremental value of copeptin for rapid rule out of acute myocardial infarction / T. Reichlin, W. Hochholzer, C. Stelzig [et al.] // J Am Coll Cardiol. - 2009. - Vol. 54, N 1. - P. 60-68.

102. Goldsmith S. R. Vasopressin as Vasopressor/ S. R. Goldsmith // American Journal of Medicine. - 1987. - Vol. 82. - Р. 1213-1219.

103. Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level / M. Katan, .N Morgenthaler, I .Widmer [et al.] // Neuro Endocrinol Lett. - 2008. - Vol. 29. - P. 341-346.

104. Holmes C. L. Science review: vasopressin and the cardiovascular system part 2 - clinical physiology / C. L. Holmes, D. W. Landry, J. T. Granton // Crit Care. - 2004. - Vol. 8, N 1. - Р. 15-23.

105. Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Congestive Heart Failure (ACTIV in CHF) Investigators: Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial / M. Gheorghiade, W. A. Gattis, C. M. O'Connor [et al.] // JAMA. - 2004. - Vol. 291, N 16. - Р. 1963-1971.

106. Aquaretic effect of lixivaptan, an oral, non-peptide, selective V2 receptor vasopressin antagonist, in New York Heart Association functional class II and III chronic heart failure patients / W. T. Abraham, A. A. Shamshirsaz, K. McFann [et al.] // J Am Coll Cardiol. - 2006. - Vol. 47, N 8. - Р. 1615-1621.

107. C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study / S. Q. Khan , O. S. Dhillon, R. J. O'Brien [et al.] // Circulation. - 2007. - Vol. 115. - Р. 2103-2109.

108. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin / N. G. Morgenthaler, J. Struck, C. Alfonso [et al.] // Clin Chem. - 2006. - Vol. 52, N 1. - P. 112-119.

109. Copeptin, a stable peptide of the arginine vasopressin precursor, iselevated in hemorrhagic and septic shock / N. G. Morgenthalter, B. MuЁller, J. Struck [et al.] // Shock. - 2007. - Vol. 28, N 2. - P. 219-226.

110. Endogenous stress response in Takotsubo cardiomyopathy and acute myocardialinfarction/ J. Meissner, H. Nef, J .Darga [et al.] // Eur J Clin Invest. - 2011. - Vol. 41, N 9. - P. 964-970.

111. Combined testing of high-sensitivity troponin T and copeptin on presentation at prespecified cutoffsimproves rapid rule-out of non-ST-segment elevation myocardial infarction / E. Giannitsis, T. Kehayova, M. Vafaie [et al.] // Clin Chem. - 2011. - Vol. 57. - P. 1452-1455.

112. Copeptin improvesearly diagnosis of acute myocardial infarction / T. Keller, S. Tzikas, T. Zeller [et al.] // J. Am Coll Cardiol.- 2010. - Vol. 55. - P. 2096-2106.

113. Diagnostic accuracy of combined cardiac troponin and copeptin assessment for early rule-out of myocardial infarction: a systematic review and meta-analysis / T. Raskovalova, R. Twerenbold, P. O. Collinson [et al] // European Heart Journal: Acute Cardiovascular Care.- 2014.- Vol. 3, N 1.- P. 18-27.

114. Copeptin and arginine vasopressin concentrations in critically ill patients/ S. Jochberger, N. G. Morgenthaler, V. D. Mayr [et al.] // J ClinEndocrinol Metab. - 2006. - Vol. 91. - P. 4381-4386.

115. C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarction / D. Kelly, I. B. Squire, S. Q. Khan [et al.] // J Card Fail. - 2008. - N 14. - P. 739-745.

116. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma / K. Kitamura, K. Kangawa, M. Kawamoto [et al.] // Biochem Biophys Res Commun. - 1993. - Vol. 192, N 2. - P. 553-560.

117. Production and secretion of adrenomedullin from glial cell tumors and its effects on cAMP production / K. Takahashi, F. Satoh, E. Hara [et al.] // Peptides. -1997. - Vol. 18. - P. 1117-1124.

118. Jougasaki M. Adrenomedullin: potential in physiology and pathophysiology / M. Jougasaki, J.C. Burnett Jr // Life Sci. - 2000. - Vol. 66. - P. 855-872.

119. Potent and long-lasting vasodilatory effects of adrenomedullin in humans. Comparisons between normal subjects and patients with chronic heart failure / M. Nakamura, H. Yoshida, S. Makita [et al.] //Circulation. - 1997. - Vol. 95. - P. 1214 -1221.

120. Parkes D. G. ACTH-suppressive and vasodilator actions ofadrenomedullin in conscious sheep / D. G. Parkes, C. N. May // J Neuroendocrinol. - 1995. - Vol. 7. - P. 923-929.

121. Parkes D. G. Direct cardiac and vascular actions of adrenomedullinin conscious sheep / D. G. Parkes, C. N. May //Br J Pharmacol . - 1997. - Vol. 120. - P. 1179-1185.

122. Vari R. C. Renal effects of adrenomedullin inthe rat / R. C. Vari, S. D. Adkins, W. K. Samson // Proc Soc Exp Biol Med. - 1996. - Vol. 211. - P. 178-183.

123. Hinson J. P. Adrenomedullin a multifunctionalregulatory peptide / J. P. Hinson, S. Kapas, D. M. Smith // Endocr Rev. - 2000. - Vol. 21, N 2. - P. 138-167.

124. Measurement of midregional proadrenomedullin in plasma with an immunoluminometricassay / N. G. Morgenthaler, J. Struck, C. Alonso [et al] //Clin Chem. - 2005. - Vol. 51. - P. 1823-1829.

125. Struck J. Identification of an adrenomedullin precursor fragment in plasma of sepsis patients / J. Struck, C. Tao, N. G. Morgenthaler [et al] // Peptides. - 2004. -Vol. 25, N 8. - P. 1369-`1372.

126. Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma / N. G. Morgenthaler, J. Struck, B. Thomas [et al] // Clin Chem. - 2004. - Vol. 50. - P. 234-236.

127. Homogeneous time-resolved fluoroimmunoassay for the measurement of midregional proadrenomedullin in plasma on the fully automated system BRAHMS KRYPTOR® / P. Caruhel, C. Mazier, J. Kunde [et al] // Clin Biochem. - 2009. - Vol. 42, N 7-8. - P. 725-728.

128. Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in ACute Heart failure) trial / A. Maisel, C. Mueller, R. Nowak [et al.] // J Am Coll Cardiol. - 2010. - Vol. 55. -P. 2062-2076.

129. Short-term mortality risk in emergency department acute heart failure / W. F. Peacock, R. Nowak, R. Christenson [et al.] // Acad Emerg Med. - 2011. - Vol. 18, N 9. - P. 947-958.

130. ADHERE Investigators. Cardiac troponin and outcome in acute heart failure / W. F. 4th Peacock, T. De Marco, G. C. Fonarow [et al.] // N Engl J Med. - 2008. - Vol. 358, N 20. - P. 2117-2126.

131. The first clinical pilot study of intravenous adrenomedullin administration in patients with acute myocardial infarction / Y. Kataoka, S. Miyazaki, S. Yasuda [et al.] // J Cardiovasc Pharmacol. - 2010. - Vol. 56, N 4. - P. 413-419.

132. Assessment of myocardial injury by serum tumour necrosis factor alpha measurements in acute myocardial infarction / M. M. Hirschl, M. Gwechenberger, T. Binder [et al.] // Eur. Heart J. - 1996. - Vol. 17. - P. 1852-1859.

132. Assessment of myocardial injury by serum tumour necrosis factor alpha measurements in acute myocardial infarction / M. M. Hirschl, M. Gwechenberger, T. Binder [et al.] // Eur. Heart J. - 1996. - Vol. 17. - P. 1852-1859.

133. Клиническая фармакология основных классов антигипертензивных препаратов / Д. В. Преображенский, Б. А. Сидоренко, Н. Е. Романова [и др.] // Consilium Medicum. - 2000. - T. 2, № 3. - C. 99-127.

134. Майчук Е. Ю. Современные представления об использовании ингибиторов ангиотензинпревращающего фермента для лечения артериальной гипертензии / Е. Ю. Майчук, И. В. Воеводина // Русский медицинский журнал (РМЖ) . - 2005. - T. 13, № 19. - С. 1287-1293.

135. Зофеноприл кардиопротективный ингибитор ангиотензинпревращающего фермента: клиническая фармакология и опыт применения при лечении артериальной гипертензии / Д. В. Преображенский, Б. А. Сидоренко, Т. В. Скавронская [и др.] // Рос. кардиол. журн. - 2006. - № 1. - С. 87-94.

136. Зофеноприл (Зокардис) - кардиоселективный ингибитор ангиотензинпревращающего фермента: особенности клинической фармакологии и перспективы применения при лечении сердечно-сосудистых заболеваний / Д. В. Преображенский, Б. А.Сидоренко, М. А. Бугримова [и др.] // Рус. мед. журн. - 2007. - № 4. - С. 3-10.

137. A review of the angiotensin-converting enzyme inhibitor, zofenopril, in the treatment of cardiovascular diseases / C. Borghi, S. Bacchelli, D. D. Esposti [et al.] // Expert Opin. Pharmacotherapy. - 2004. - Vol. 5. - P. 1965-1977.

138. Subissi A. Preclinical profile of zofenopril: an angiotensin converting enzyme ingibitor with peculiar cardioprotective properties / A. Subissi, S. Evangelista, A. Giacbetti // Cardiovasc. Drug Rev. - 1999. - Vol. 17. - P. 115-133.

139. Оптимальная терапия острого инфаркта миокарда: место и роль ингибиторов АПФ / авт. обзора Н. Генш ; с комментарием проф. А. Н. Пархоменко // Medicine review. ? 2013. ? № 1. ? С. 32?38.

140. Sites of first-pass bioactivation (hydrolysis) of orally administered zofenopril calcium in dogs / R. A. Morrison, D. E. Burkett, M. E. Arnold [et al.] // Pharm. Res. - 1991. - Vol. 8. - P. 370-375.

141. Disposition of zofenopril calcium in healthy subjects / S. M. Singhvi, J. E. Foley, D. A. Wilard [et al.] // J. Pharm. Sci. - 1990. - Vol. 79. - P. 970-973.

142. Latini R. On behalf of the Angionten sin converting Enzymе Inhibitor Myocardial lnfarction Collaborative Grouр. Clinical effects of early angiontensin-converting еnzymе inhibitor treatment for acute myocardial infarction are similar in the presence and absence of аsрirin: systematic overview of individual data from 96,712 randomized patients / R. Latini, G. Тоgnоni, А. Р.Mаtоni // J. Amer. Coll. Cardiol. - 2000. - Vol. 35. - P. 1801-1807.

143. The role of zofenopril in myocardial protection during cardioplegia arrest: an isolated rat heart model / C. Leva, G. Mariscalco, S. Ferrarese [et al.] // J. Card. Surg. - 2006. - Vol. 21. - P. 44-49.

144. Sun Y. Angiotensin converting enzyme inhibition in heart, kidney, and serum studied ex vivo after adminidtration of zofenopril, captopril, and lisinopril / Y. Sun, F. A. Mendelsohn // J. Cardiovasc. Prarmacol. - 1991. - Vol. 18. - P. 478-486.

145. Converting enzyme inhibitors and the role of the sufhydryl group in the potentiation of exo- and endogenous nitrovasodilators / W. H. Van Gilst, P. A. de Graeff, M. J. de Leeuw [et al.] // J. Cardiovasc. Pharmacol. - 1991. - Vol. 18. - P. 429-436.

146. Evangelista S. Antioxidant and cardioprotective properties of the sulphydryl angiotensin-converting enzyme inhibitor zofenopril / S. Evangelista, S. Manzini // J. Int. Med. Res. - 2005. - Vol. 33. - P. 42-54.

147. Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel / C. A. Sargent, P. G. Sleph, S. Dzwonczyk [et al.] // J. Pharmacol. Exp. Ther. - 1993. - Vol. 265. - P. 609-618.

148. Pharmacokinetic and pharmacodynamic comparative study of zofenopril and enalapril in healthy volunteers / A. Marzo, L. Dal Bo, P. Mazzucchelli [et al.] // Arzneimittelforschung. - 2002. - Vol. 52. - P. 233-242.

149. Ranadive S. A. Relative lipophilicities and structural-pharmacological considerations of various angiotensin-converting enzyme (ACE) inhibitors / S. A. Ranadive, A. X. Chen, A. T. Serajuddin // Pharm. Res. - 1992. - Vol. 9. - P. 1480-1486.

150. Comparison of zofenopril and lisinopril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE-inhibitors in experimental heart failure / H. Buikema, S. H. Monnink, R. A. Tio [et al.] // Br. J. Pharmacol. - 2000. - Vol. 130. - P. 1999-2007.

151. Zofenopril inhibits the expression of adhesion molecules on endothelial cells by reducing reactive oxygen species / L. Cominacini, A. Pasini, U. Garbin [et al.] // Amer. J. Hypertens. - 2002. - Vol. 15, N 1. - P. 891-895.

152. The role of zofenopril in myocardial protection during cardioplegia arrest: an isolated rat heart model / C. Leva, G. Mariscalco, S. Ferrarese [et al.] // J. Card. Surg. - 2006. - Vol. 21. - P. 44-49.

153. Cardioprotective effect of zofenopril in perfused rat heart subjected to ischemia and reperfusion / S. Frascarelli, S. Ghelardoni, S. Ronca-Testoni [et al.] // J. Cardiovasc. Pharmacol. - 2004. - Vol. 43. - P. 294-299.

154. Effect of sulfhydryl and non-sulfhydryl angiotensin-converting enzyme inhibitors on endothelial function in essential hypertensive patients / A. F.Pasini, U. Garbin, M. C. Nava [et al.] // Amer. J.Hypertens. - 2007. - Vol. 20. - P. 443-450.

155. Effect of Captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the Survival and Ventricular Enlargement trial / M. A. Pfeffer, E. Braunwald, L. A. Moye [et al.] // New Engl. J. Med. - 1992. - Vol. 327. - P. 669-677.

156. Effects of captopril оn ischaemic events after MI. Results of the Survival and Ventricular Enlargement for the Survival and Ventricular Enlargement (SAVE) trial Investigators / J. D. Rutherford, М. А. Pfeffer, L. A. Moye [еt al.] // Circulation. - 1994. - Vol. 90. - P. 1731-1738.

157. Evangelista S. Антиатеросклеротическое действие ингибиторов АПФ / S. Evangelista // Consilium Medicum. - 2007. - Vol. 5. - P. 24-26.

158. Sulfhydryl angiotesin-converting ensyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essencial hypertension / C. Napoli, V. Sica, F. de Nigris [et al.] // Amer. Heart J. - 2004. - Vol. 148. - P. 1-7.\

159. Scribner A.W. The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress / A. W. Scribner, J. Loscalzo, C. Napoli // Eur. J. Pharmacol .- 2003. - Vol. 482. - P. 95-99.

160. Thomas G. Von Lueder. RAAS Inhibitors and Cardiovascular Protection in Large Scale Trials /Thomas G. Von Lueder, Henry Krum // Cardiovascular Drugs and Therapy. - 2013. - Vol. 27, N 2. - Р. 171-179.

161. For the Survival of Myocardial Infarction Long-Term Evaluation (SMILE) Study Investigators. The effect of the angiotensin-converting enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction / E. Ambrosioni, C. Borghi, B. Magnani [et al.] // New Engl. J. Med. - 1995. - Vol. 332. - P. 80-85.

162. Borghi C. Survival of Myocardial Infarction Long-term Evaluation-2 Working Party. Double-blind comparison between zofenopril and lisinopril in patients with acute myocardial infarction: results of the Survival of Myocardial Infarction Long-term Evaluation-2 (SMILE-2) study/ C. Borghi, E. Ambrosioni // Am. Heart J. - 2003. - Vol. 145. - P. 80-87.

163. Borghi C. Survival of Myocardial Infarction Long-term Evaluation Study Group. Effects of zofenopril on myocardial ischemia in post-myocardial infarction patients with preserved left ventricular function: the Survival of Myocardial Infarction Long-term Evaluation (SMILE)-ISCHEMIA study / C. Borghi, E. Ambrosioni // Amer. Heart J. - 2007. - Vol. 153. - P. 7-14.

164. Comparison between zofenopril and ramipril in combination with acetylsalicylic acid in patients with left ventricular systolic dysfunction after acute myocardial infarction: results of a randomized, double-blind, parallel group, multicenter, European study (SMILE-4) / C. Borghi, E. Ambrosioni, S. Novo [et al.] // Clin. Cardiol. - 2012. - Vol. 35. - P. 416-423.

165. Borghi C. Cardioprotective role of ACE-I in patients with acute MI: THE SMILE -OVERALL project / C. Borghi // J Am Coll Cardiol. - 2012. - Vol. 59, N 13. - P. 454.

166. Adrenomedullin: angiogenesis and gene therapy / N. Nagaya, M. Hidezo, S. Murakami [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2005. - Vol. 288. - P. 1432-1437.

167. Morgenthaler N.G. Copeptin: a biomarker of cardiovascularand renal function / N. G.Morgenthaler // Congest Heart Fail. - 2010. - Vol. 16, N 14. - Р. 37-44.

168. C-terminalprovasopressin (copeptin) as a novel and prognosticmarker in acute myocardial infarction: LeicesterAcute Myocardial Infarction Peptide (LAMP) study / S. Q. Khan, O. S. Dhillon, R. J. O'Brien [et al.] // Circulation. - 2007. - Vol. 115, N 16. - Р. 2103-2110.

169. Tenderenda-Banasiuk E. Serum copeptin levels in adolescents with primary hypertension / E. Tenderenda-Banasiuk, A. R. Wasilewska, Filokonocz // Pediatr. Nephrol. - 2014. - Vol. 29. - P. 423-429.

170. Umer S. Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome / S. Umer, M. Khaleghi // Clin Endocrinol Metab. - 2009. - Vol. 94, N 7. - Р. 2558-2564.

171. Enhцrring S. Сopeptin is an independent predictor of diabetic heart disease and death / S. Enhцrring, B. Hedbland, P. M. Nielsson // Heart Journal. - 2015. - Vol 169, N 4. - Р. 549-556.

172. Asfeng C. L. Copeptin , a surrogate marker for arginine vasopressin secretion, is associated with higher glucose and insulin concentrations but not higher blood pressure in obese men / C. L. Asfeng, U. B. Andersen, A. Linneberg // Diabetic Medicine. - 2014. - Vol. 31. - P. 728-732.

173. Nenhold S. Comparison of copeptin, B-type natri-pro-B-type natriuretic peptide in patients with chronic heart failure prediction disease / S. Nenhold, M. Huelsmann, G. Strunk // J.Am.Coll.Card. - 2008. - Vol. 52, N 4. - P. 266-272.

174. C-terminal provasopressin(copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMALstudy / A. A. Voors, S. von Haehling, S. D. Anker [et al.] // Eur Heart J. - 2009. - Vol. 30. - Р. 1187-1194.

175. Value of Biomarkers in Patients with Heart Failure / D.Tousoulis, E. Oikonomou, G. Siasos; C. Chrysohoou // Predictive Current Medicinal Chemistry. - 2012. - Vol. 19, N 16. - Р. 2534-2547.

176. Rose A. M. Mechanism for the “anti-lipolitic” action of vasopressin in the starved rat / A. M. Rose, D. H. Williamson // Biochem. J. - 1983. - Vol. 212, N 3. - P. 899-902.

177. Rossi R. Mechanisms of the effects of vasopressin on plasma levels of free fatty acids and triglycerids in pygmy goats / R. Rossi, E. Scharrer // Comp.Biochem.Physiol. - 1993. - Vol. 104. N 2. - P. 287-290.

178. Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors / Т.Yurugi-Kobayashi, H. Itoh, Т. Schroeder [et al.] // Arterioscler Thromb Vasc Biol. - 2006. - Vol. 26, N 9. - P. 1977-1984.

179. Prognostic value of mid-regional pro-adrenomedullin levels taken on admission and discharge in non-ST-elevation myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) II study / O. S. Dhillon, S. Q. Khan, H. K. Narayan [et al.] // J. Am. Coll. Cardiol. - 2010. - Vol. 56, N 2. - P. 125-133.

180. Yanagawa B. Adrenomedullin: molecular mechanisms and its role in cardiac disease / B. Yanagawa, N. Nagaya // Amino Acids. - 2007. - Vol. 32, N 1. - P. 157-164.

181. Adrenomedullin: angiogenesis and gene therapy / N.Nagaya, M.Hidero, S.Murakami [et al.] // J.Am.Physiol. Regul.Integr.Comp.Physiol. - 2005. - Vol. 288. - P. 1432-1437.

182. Effect of sulfhydryl and nonsulfhydrylangiotensin-converting enzyme inhibitors on endothelial function in essential hypertensive patients / A. F. Pasini, U. Garbin, M. C. Nava [et al.] // Am J Hypertens. - 2007. - Vol. 20. - P. 443-450.

183. Коваленко В. М. Регіональні медико-соціальні проблеми хвороб системи кровообігу. Динаміка та аналіз. (Аналітично-статистичний посібник) / Під ред. В.М. Коваленка, В.М. Корнацького - К., 2013. - 239 с.

184. Коваленко В. М. Сердечно-сосудистые заболевания и ренин-ангиотензиновая система / В. Н. Коваленко, Т. В. Талалаева, В. В. Братусь - К.: Морион, 2013. - 232 с.

185. Fawcett T. ROC graphs: Notes and practical considerations for researchers / T. Fawcett // ReCALL. - Vol. 31, N HPL-2003-4. - P. 1?38.

186. Бикел П. Математическая статистика / Бикел П., Доксам К.- М.; Финансы и статситика, 1983. - Вып.1-2.

187. Гублер Е.В. Применение непараметрических критериев статистики в медико-биологических исследованиях / Е.В. Гублер, А.А. Генкин. - Л.: Медицина, 1973. -141 с.

188. Impact of copeptin on diagnosis, risk stratification, and intermediate-term prognosis of acute coronary syndromes / D. Afzali, M. Erren, H.-J. Pavenstдdt [et al.] // Clinical Research in Cardiology. -2013. -Vol. 102, N 10. - P. 755-763.

Размещено на Allbest.ru

...

Подобные документы

Работы в архивах красиво оформлены согласно требованиям ВУЗов и содержат рисунки, диаграммы, формулы и т.д.
PPT, PPTX и PDF-файлы представлены только в архивах.
Рекомендуем скачать работу.