Полиморфизм генов, белковые продукты которых играют роль в развитии воспаления, при ишемическом инсульте

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Список использованных сокращений

АГ - артериальная гипертензия

АД - артериальное давление

АПК - антигенпрезентирующие клетки

ГКГ - главный комплекс гистосовместимости

ГЭБ - гематоэнцефалический барьер

ДИ - доверительный интервал

ИБС - ишемическая болезнь сердца

ИИ - ишемический инсульт

ИМ - инфаркт миокарда

ЛПНП - липопротеины низкой плотности

МА - мерцательная аритмия

МРТ - магнитно-резонансная томография

ОШ - отношение шансов

ПДРФ - полиморфизм длины рестрикционных фрагментов

п.н. - пара нуклеотидов

ПЦР - полимеразная цепная реакция

ПЦР-SSP - ПЦР с использованием набора аллелеспецифических праймеров

РААС - ренин-ангиотензин-альдостероновая система

мм.рт.ст. - миллиметр ртутного столба

ср. возраст - средний возраст

ФФК - фосфофруктокиназа

ХС - холестерин

цАМФ - циклический аденозинмонофосфат

цГМФ - циклический гуанозинмонофосфат

ЦНС - центральная нервная система

ЭДТА - этилендиаминтетраацетат

ЭКГ - электрокардиография

ACE -ангиотензин-превращающий фермент

ACE - ген, кодирующий ангиотензин-превращающий фермент

apoE - аполипопротеин Е

APOE - ген, кодирующий аполипопротеин Е

CADASIL - церебральная аутосомно-доминантная артериопатия с субкортикальными инфарктами и лейкоэнцефалопатией

CTLA4 - антиген 4 цитотоксических Т-лимфоцитов (Cytotoxic T-Lymphocyte Antigen 4)

dH2O - дистилированная H2O

DMSO - диметилсульфоксид

EM - максимизация математического ожидания (expectation maximization)

eNOS - ген, кодирующий эндотелиальную синтазу NO

FGA -альфа-фибриноген

FGA - ген, кодирующий альфа-фибриноген

FGB - бета-фибриноген

FGB - ген, кодирующий бета-фибриноген

GWAS - полногеномный поиск ассоциаций (genome-wide association study)

IFNг - интерферон гамма

IFNG - ген, кодирующий интерферон гамма

IL-4 - интерлейкин 4

IL4 - ген, кодирующий интерлейкин 4

IL-6 - интерлейкин 6

IL6 - ген, кодирующий интерлейкин 6

LPL - липопротеинлипаза

LPL - ген, кодирующий липопротеинлипазу

LTA - лимфотоксин альфа

LTA - ген, кодирующий лимфотоксин альфа

MTHFR - ген, кодирующий метилентетрагидрофолатредуктазу

PDE4D - фосфофдиэстераза 4D

PDE4D - ген, кодирующий фосфофдиэстеразу 4D

QTL - локус количественных признаков (quantitative trait locus)

SD - стандартное отклонение (standard deviation)

SDS - додецилсульфат натрия

SHRSP - склонные к возникновению инсульта спонтанно-гипертензивные крысы (spontaneously hypertensive stroke-prone rats)

SNP - однонуклеотидный полиморфизм (single nucleotide polymorphism)

TGFB1 - ген трансформирующего фактора роста бета 1

TNF - фактор некроза опухоли альфа

TNF - ген фактора некроза опухоли альфа

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